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Peace and Health,
 Priscilla Slagle M.D.

 ALTERNATIVE HEALTH PRODUCTS & ALTERNATIVE MEDICINE
 PRISCILLA SLAGLE, M.D. or Cathy Jones, Assistant
 Email: thewayup@dc.rr.com
Phone: 1 (760) 322-7797, Fax: 760-322-7608

The Natural Treatment of Stress, Low Moods & Depression

If you or anyone you know is experiencing severe stress, low moods or depression the information in this newsletter can dramatically improve lives.

The natural program for relieving depression program outlined in my book The Way Up From Down    & available on my website at  NATURAL TREATMENT FOR DEPRESSION  has helped tens of thousands of people over the years. Most of those who carefully followed the program experienced relief in 2-6 weeks.  The program consists of nutritional supplements & a healthy diet without sugar & alcohol. If you have carefully followed the original program for at least six weeks & do not feel completely improved, I recommend adding the following supplements:

Vitamin B12 Methylcobalamin: (please note that this replaces the B/12 listed in the book) I prefer the methylated form of Vitamin B12, which was not available at the time the book was written.  It is the most active form of vitamin B12 in the body, especially the brain and nervous system.  Also see my in depth newsletter on B12 & folic acid.  Most forms of B12 on the market are cyanocobalamin which is a low-grade, low-quality form of vitamin B-12 that's used by all the cheap vitamin manufacturers.  Methylcobalamin is the form of B12 your body must have.  When you use a non methylated form, your body must methylate it for it to be useful.  However, approximately 45% of people have a genetic trait called MTHFR (Methylene tetrahydrofolate reductase) defect & cannot methylate or utilize non methylated forms.  For this reason I now always recommend supplementation with methylated B12 & folic acid.

For more information see "Methylation Problems Lead to 100s of Diseases" by pharmacist Suzy Cohen.

You can read more interesting details re Methylation Problems at New Story of Vitamin B12 by Ed Sharpe

Optimized Folate (L-Methylfolate):  Is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. Folate benefits cardiovascular health and nervous system function, by depleting excess homocysteine, which is a damaging chemical produced in the body.

Folic acid is the synthetic/ unmetabolized form of folate.  Many supplements are only folic acid.  But again the 45% of the population who cannot methylate cannot properly utilize these forms of folic acid  It is better to avoid straight folic acid & to only use the methylated form. Research has shown that methyl folate can deliver folate immediately, without the need for conversion.

Methylated folate has been used to support a range of health concerns, including:

• Mood disorders – Methyl folate represents a better option for patients due to its greater bioavailability and lack of side effects.
• Homocysteine reducer – A folate enriched diet, or supplementation with bioavailable methyl folate has been shown to lower homocysteine levels, an amino acid associated with a higher risk of cardiovascular problems.
• Diabetic peripheral neuropathy – A randomized, double-blind, placebo-controlled trial found that patients with diabetic neuropathy experienced quality of life improvements with methyl folate.
• Skin disorders – A recent 2013 study found high proportions of methyl folate in the epidermis, even as serum folate levels dropped. This has suggested it as a potential UV skin protectant and an option for skin conditions such as psoriasis.
• Prenatal supplementation – Methyl folate supplementation ensures adequate folate levels necessary to support normal neural development to avoid spina bifida in offspring.

LGlutamine: Is a major energy source for the brain. If there is not enough L-glutamine the brain relies on glucose for fuel.  An over production of glucose can lead to obesity, diabetes and many other diseases.

The two amino acids I most frequently prescribe in my practice are L-glutamine & L-tyrosine. Though glutamine has multiple functions, as you will see, the benefits  most often achieved are improved mood, focus, concentration, memory, &  energy. Glutamine is often depleted in those with yeast overgrowth, the depletion of which is partially responsible for the "brain fog" in those individuals.

Glutamine plays a key role in the metabolism, structure & function of the entire gastrointestinal tract. It is the primary energy source for the cells that line your intestines & is essential to keeping them healthy.

Potential uses of glutamine:

• General energy booster
• Improve low moods
• Memory, focus, concentration
• Maintaining healthy blood sugar levels already in the normal range
• Detoxify ammonia
• Improve stress tolerance
• Muscle support & building especially with prolonged exercise or for athletes & body builders
• Supports growth hormone release - in doses of 2 gms daily
• Improves mental fatigue
• Gastrointestinal health
• Helps make DNA (cellular genetic material)

Please see Dr. Slagle's Newsletter on Glutamine.

Vitamin D:  Studies  have shown a link between vitamin D deficiency and depression. In a 2013 meta-analysis, researchers noticed study participants with depression also had low vitamin D levels. The same analysis found that, statistically, people with low vitamin D were at a much greater risk of depression.

The researchers believe that because vitamin D is important to brain function: Insufficient nutrient levels may play a role in depression and other mental illnesses. An earlier 2005 study identified vitamin D receptors in the same areas of the brain associated with depression.

Click link for a comprehensive look at the research on Vitamin D

Omega-3 Fatty Acids: People who suffer from mood disorders such as depression benefit from fish oil supplementation which contains Omega 3. Studies have shown depressed people have reduced RBC membrane or serum DHA and EPA which are components of Omega-3 Fatty Acids.

Researchers at the University of Sheffield and many other studies found that fish oil supplements alleviated the symptoms of depression, bipolar disorder and psychosis. Dosages needed for psychiatric conditions may be up to 9 grams daily.
  
Additional studies have found that people taking antidepressant medications and still suffering from depression, may have reduced intensity of depression, anxiety, sleep disturbances, and sexual dysfunction when supplementing with omega-3 fatty acids.

A review of 35 randomized controlled trials on omega-3 fatty acids and depression revealed the more severe the depression, the more likely omega-3's will help improve mood.  They found the EPA component to be more effective with depression than the DHA component.

For more information, see my “Benefits of Omega-3” newsletter. 

Probiotics: In the double-blind placebo-controlled and randomized parallel group study conducted by Messaoudi et al., healthy volunteers took Lactobacillus helveticus R0052 and Bifidobacterium longum or a placebo for 30 days; the results showed that psychological stress levels, including depression scores, were decreased in subjects who took the probiotics regularly. A study performed by Mohammadi et al. indicated that consuming a probiotic yogurt or a multispecies probiotic capsule for six weeks had beneficial effects on the mental health biomarkers of petrochemical workers. Another study, conducted by Benton et al., found that probiotic yogurt improved the mood of those with an initially poor mood. A study by Akkasheh found that eight weeks of administration of probiotics to patients with major depressive disorder (MDD) had beneficial effects on Beck Depression Inventory scores. The effects of probiotics on human health, especially psychiatric disorders, have recently emerged as an area of interest in neuroscience. The regulation of probiotics through diet may have critical benefits for preventing and treating depression.

Read  “Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials”  for more information.

Since most people don’t know when they are overly stressed or depressed. You can take a quick test called the Zung Self Rating Depression Scale .  There are 2 pages, 20 questions. Answer what best fits you most of the time. Take the test on the first page & see how to score & interpret on the second page.  If your score is more than 50 you would feel better if you made some of the changes explained in my book & here.

If you think you are happy that is enough to be happy.  If you are unable to think this, there may be some element of low mood.

I hope you have found this newsletter helpful. All of the supplements mentioned in this newsletter & much more are available on my website, so click the link & start to feel good again! 

Peace and Health,

Priscilla Slagle M.D.

 

ALTERNATIVE HEALTH PRODUCTS & ALTERNATIVE MEDICINE

PRISCILLA SLAGLE, M.D. or Cathy Jones, Assisitant

Email: thewayup@dc.rr.com

Phone: 1 (760) 322-7797

Fax: 760-322-7608

Worried About Bone Health or Osteoporosis? Try Bone Maximer III

Bone Maximizer® III

As we age, our bone mineral density decreases,  increasing the risk of fracture. It occurs most frequently in elderly women but can affect men as well. Osteoporosis may be due to menopause, inactivity, drugs, thin body build, poor lifestyle, or dietary and nutritional deficiencies.

 

Some prescription drugs which can lead to bone loss are:

• Corticosteroid: cortisone (Cortone), prednisone (Deltasone, Meticorten, Orasone, Prednicot)
• Anti-Cancer Drugs: anastrozole (Arimidex), exemestane (Aromasin), letrozole (Femara)
•  Antidepressant Drugs: citalopram (Celexa), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft)
• GERD Drugs: cimetidine (Tagamet), famotidine (Calmicid, Fluxid, Mylanta AR, Pepcid), ranitidine (Tritec, Zantac)
• Diabetes Drugs: pioglitazone (Actos), rosiglitazone (Avandia)

Therefore, maximizing bone health involves the careful selection of a positive blend of nutrients designed to support bone building without accelerating bone breakdown.

 

Bone Maximizer® III contains microcrystalline hydroxyapatite concentrate (MCHC) along with other vital bone and joint nutrients. These other vital bone and joint nutrients include :

• Calcium
• Vitamin D
• Vitamin C
• Vitamin K2
• Magnesium Glycinate
• Zinc
• Boron- Contributes to estrogen function & calcium/magnesium absorption.
• Silica
• MSM (Methylsulfonylmethane)
• Vitamin D3
• Glucosamine Chondroitin

   

For more information see my DO YOU HAVE STRONG BONES OR ARE YOU AT RISK FOR OSTEOPOROSIS?

 

ALTERNATIVE HEALTH PRODUCTS & ALTERNATIVE MEDICINE

PRISCILLA SLAGLE, M.D. or Cathy Jones, Assisitant

Email: thewayup@dc.rr.com

Phone: 1 (760) 322-7797

Fax: 760-322-7608

Ready to Lose Weight in 2017? Try These Two Natural Supplements

ORDER NOW THROUGH JANUARY 31, 2017 AND RECEIVE AN ADDITIONAL 10% OFF. JUST ENTER CODE "WEIGHT" IN THE PROMO BOX.

INTEGRA-LEAN

 

Use this fat-fighting extract to inhibit the enzymes that turn glucose and triglycerides into stored fat.  Try Integra-Lean® Aftrican Mango Irvingia today!

 

For help on your journey to healthy weight loss, look no further than genuine African mango. Integra-Lean® African Mango Irvingia extract is the exact ingredient used in the study that made Irvingia gabonensis so famous.

Irvingia gabonensis extract has been shown to help support leptin sensitivity in overweight people. Leptin is a hormone produced by fat cells that tell our brain we have eaten enough. It also helps break down of stored triglycerides in fat cells.

Heavy individuals have high blood levels of leptin which indicates that their cells have become resistant to the hormone that is supposed to prevent them from putting on so many fat pounds.

Irvingia has demonstrated beneficial effects upon leptin blood levels, followed by both weight loss and reduced waistlines.

Irvingia also benefits other key aspects of healthy metabolism:

• Glycerol-3-phosphate dehydrogenase is an enzyme involved in converting ingested starch and sugar calories to body fat. Irvingia has been shown to reduce the activity of glycerol-3-phosphate dehydrogenase, helping to reduce starch and sugar calorie impact on body fat.
• Alpha-amylase Research suggests irvingia can inhibit the alpha-amylase enzyme. This can help support a slower rate of carbohydrate absorption and reduce the caloric impact of starchy and sugary foods.
• Adiponectin irvingia helps support healthy levels of adiponectin, a hormone that helps maintain insulin sensitivity on the membranes of energy-producing cells. Overweight people need to maintain healthy levels of adiponectin in order to support normal blood sugar and metabolic fitness. 

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.

This information provided by Life Extension Foundation.

 

Green Coffee Extract, CoffeeGenic®

 

People who take extraordinary steps to limit their carbohydrate exposure may still be experiencing higher-than-desired blood sugar levels throughout the day.

Studies show even in people with normal fasting glucose levels, gaining control of after-meal surges which may provide additional support for cardiovascular and metabolic health.

Green coffee extract is a natural compound that addresses this widespread problem. In fact, a 400 mg dose was shown to induce a remarkable 24% drop in after-meal blood sugar after 30 minutes while 200 mg generated a 14% drop! The reason is chlorogenic acid, a polyphenol found in the green coffee bean.

Chlorogenic acid has been shown to inhibit excess activity of glucose-6-phosphatase. The glucose-6-phosphatase enzyme triggers glucose formation from non-carbohydrate substrates and glycogen release from the liver, both of which can create excess glucose in the blood. Neutralizing excess glucose-6-phosphatase is essential for most people to achieve optimal glucose control.

Another means by which chlorogenic acid supports healthy after-meal glucose levels is by targeting the inhibition of the alpha-glucosidase enzyme. This intestinal enzyme breaks apart complex sugars and enhances their absorption into the bloodstream.

Chlorogenic acid also increases the signal protein for insulin receptors in liver cells.

Why CoffeeGenic® Green Coffee Extract?

Coffee grows on trees and the fruit is a berry. The berry contains green seeds, which are the “coffee beans.” The outer part of the berry is washed away to get to the seeds. The seed has a higher amount of phenolic acids than the berry.

The problem with the roasted coffee you drink is that much of the beneficial phenolic content of the coffee beans is destroyed during the roasting process.

CoffeeGenic® Green Coffee Extract is produced from these green coffee beans. The resulting green coffee extract is standardized to 50% chlorogenic acids for maximum potency & maximum effect in helping to maintain healthy glucose levels already within normal range.

This higher potency standalone version is the same clinical dose shown to induce a 24% drop in after-meal glucose spikes within 30 minutes and is ideal for those who need additional glucose management support.

This information provided by Life Extension Foundation.

 For more supplements that help with weight loss click WEIGHT LOSS

ALTERNATIVE HEALTH PRODUCTS & ALTERNATIVE MEDICINE

PRISCILLA SLAGLE, M.D. or Cathy Jones, Assisitant

Email: thewayup@dc.rr.com

Phone: 1 (760) 322-7797

Fax: 760-322-7608